Secretome: Full set of secreted proteins.
Most eukaryotic proteins are synthesized in the cytosol, and many need to be sorted to different subcellular locations. Extracellular proteins contain an N-terminal targeting sequence that is recognized by the secretory pathway, and these signal peptides(SPs) are responsible for targeting proteins to the endoplasmic reticulum for subsequent transport through the secretory pathway. In most cases, SPs are cleaved off by specific signal peptidases.
